浠婂ぉ鏄細

瀹為獙瀹よ祫璁綉

绋庡厜鍘氾細涓轰粈涔堣鍋氳剛璐ㄧ粍瀛︾爺绌讹紵

瀹為獙瀹よ祫璁綉鏃堕棿:2019-05-25 鐐瑰嚮: 娆?/span> 鐧惧害鎼滅储

銆愬璇汇€?/strong>绮惧噯鍒嗘瀽鎴戜滑鐨勬垚鍔熸晠浜嬬郴鍒?鍐欏湪鍓嶉潰鐨勮瘽 绮惧噯鍒嗘瀽閲忓寲閲婅兘鎴戜滑鐨勬垚鍔熸晠浜嬬郴鍒楁爮鐩紝鏄疭CIEX甯姪绉戝瀹朵滑鍒嗕韩鏈夋剰涔夌殑绉戝鍙戠幇鍜岀爺绌舵垚鏋滅殑绉戞櫘骞冲彴銆傛垜浠湡寰呰鏇村鐨勪汉鎰熷彈鍒扮瀛﹀拰璐ㄨ氨鐨勫姏閲忥紝璁╄川璋辨敼鍙樻瘡涓汉鐨勭敓娲诲缁堟槸SCIEX鏈€缇庡ソ鐨勬効鏅€係CIEX闈炲父鑽e垢鑳藉鍙備笌鍒拌繖涓€绯诲垪鏈夎叮鐨勭瀛﹀彂鐜?.....
TAG鏍囩锛?绋庡厜鍘?/a> 鑴傝川缁勫鐮旂┒ 鑴傝川缁勫

“绮惧噯鍒嗘瀽”鎴戜滑鐨勬垚鍔熸晠浜嬬郴鍒?/strong>

——鍐欏湪鍓嶉潰鐨勮瘽

“绮惧噯鍒嗘瀽•閲忓寲閲婅兘”——鎴戜滑鐨勬垚鍔熸晠浜嬬郴鍒楁爮鐩紝鏄疭CIEX甯姪绉戝瀹朵滑鍒嗕韩鏈夋剰涔夌殑绉戝鍙戠幇鍜岀爺绌舵垚鏋滅殑绉戞櫘骞冲彴銆傛垜浠湡寰呰鏇村鐨勪汉鎰熷彈鍒扮瀛﹀拰“璐ㄨ氨”鐨勫姏閲忥紝”璁╄川璋辨敼鍙樻瘡涓汉鐨勭敓娲?rdquo;濮嬬粓鏄疭CIEX鏈€缇庡ソ鐨勬効鏅€係CIEX闈炲父鑽e垢鑳藉鍙備笌鍒拌繖涓€绯诲垪鏈夎叮鐨勭瀛﹀彂鐜拌繃绋嬩腑锛屽鎴锋垚鍔熷氨鏄疭CIEX鐨勬垚鍔燂紝鎵€浠ワ紝鎮ㄨ鍒扮殑鏄?“鎴戜滑锛圫CIEX鍜屽鎴凤級鐨勬垚鍔熸晠浜?rdquo;銆?/p>

鏈湡绉戝瀹剁◣鍏夊帤锛屾垜浠竴璧疯皥璋堣繖浜涘勾杩呯寷鍙戝睍鐨勮剛璐ㄧ粍瀛?Lipidomics)銆?/p>

 

绋庡厜鍘氱爺绌跺憳 涓汉绠€浠?/strong>

绋庡厜鍘氾細涓轰粈涔堣鍋氳剛璐ㄧ粍瀛︾爺绌讹紵

涓闄㈤仐浼犲彂鑲叉墍鍒嗗瓙鍙戣偛鐢熺墿瀛﹀浗瀹堕噸鐐瑰疄楠屽鐮旂┒鍛橈紝鍗氬锛屽叆閫変腑绉戦櫌"鐧句汉璁″垝”锛涚幇浠讳腑绉戦櫌閬椾紶鍙戣偛鎵€鎵€绾у叕鍏辨妧鏈腑蹇冧富浠伙紱 European J Lipid Sci Technol鏉傚織缂栧锛涗腑鍥界粏鑳炵敓鐗╁瀛︿細缁嗚優浠h阿鍒嗕細鍓細闀匡紝涓浗鐢熺墿鐗╃悊鍗忎細浠h阿鐢熺墿瀛﹀垎浼氱悊浜嬶紝涓浗鐥呯悊鐢熺悊瀛︿細鍐呭垎娉屼笌浠h阿涓撲笟濮斿憳浼氱悊浜嬶紝涓浗鎶楃檶鍗忎細鑲跨槫浠h阿涓撲笟濮斿憳浼氬鍛橈紱浣滀负澶т細涓诲腑宸叉垚鍔熶妇鍔炲洓灞奓ipidall鑴傝川浠h阿鍥介檯浼氳銆傞暱鏈熶粠浜嬪墠娌跨粍瀛︽妧鏈紑鍙戙€佸姛鑳芥€у垎瀛愮粨鏋勯壌瀹氱爺鍙戙€佷唬璋㈡満鍒剁浉鍏崇殑鐮旂┒宸ヤ綔銆傝繎骞存潵鍦⊿cience, Nature, Nature Med., Immunity, EMBO Mol Med, PNAS, Nature Comm锛孞 Clin Invest, J Cell Biol, Redox Biol, Neurobiol Aging, Biochim Biophys Acta, J Biol. Chem, J Lipid Res绛夋湡鍒婂彂琛?20浣欑瘒鍏充簬浠h阿鐨勮鏂囷紝鍙戣〃SCI璁烘枃鎬诲奖鍝嶅洜瀛愮害800锛岃寮曠敤6600浣欐锛孒-index 45锛涚洰鍓嶇殑宸ヤ綔鏂瑰悜鍖呮嫭寮€鍙戝悇绫荤敓鐗╂牱鍝佺殑楂橀€氶噺銆佽秴楂樿鐩栫巼銆佽秴楂樼伒鏁忓害鑴傝川缁勫銆佸墠娌夸唬璋㈢粍瀛﹀強浠h阿娴佹妧鏈紝鐮旂┒浠h阿璋冩帶鏈哄埗銆佷唬璋㈠紓甯稿拰閲嶅ぇ鐤剧梾鐨勫唴鍦ㄨ仈绯荤瓑銆?/p>

 

浠€涔堟槸鑴傝川缁勫锛岃剛璐ㄧ粍瀛﹀拰浠h阿缁勫鏈変粈涔堝尯鍒紵

杩欎釜闂鐨勭瓟妗堟潵鑷◣鍏夊帤鑰佸笀鍦ㄧ瀛︾綉blog锛歡shui鐨勪釜浜哄崥瀹㈢殑缃《鍗氭枃銆婅剛璐ㄧ粍瀛?vs 浠h阿缁勫銆嬨€傛帹鑽愬ぇ瀹跺叧娉ㄧ◣鑰佸笀鐨刡log锛岄€氳繃绉戝瀹剁殑瑙嗚浜嗚В鏇村鍏充簬鑴傝川缁勫銆佷唬璋㈢粍瀛︾爺绌剁殑鏂板彂鐜版柊杩涘睍銆?/p>

鎴戜滑鐭ラ亾锛屼唬璋㈡槸鐢熺墿浣撳唴鍚勭鍖栧鍙嶅簲鐨勬€荤О锛屾槸鍔ㄦ鐗╂渶涓洪噸瑕佺殑鐢熷懡娲诲姩涔嬩竴锛涗釜浣撻€氳繃鍚勭浠h阿璋冭妭鏉ラ€傚簲鍐呭鐜鐨勫彉鍖栵紝鏄敓鍛芥椿鍔ㄧ殑鍩烘湰鐗瑰緛涔嬩竴銆?strong>“浠h阿缁?rdquo;鏄敓鐗╂牱鏈腑鎵€鏈変唬璋㈢墿鐨勯泦鍚堛€備唬璋㈢墿绉嶇被绻佸锛堝彲鑳借秴杩囩櫨涓囩锛夈€佺粨鏋勫鏍? 鍦ㄧ敓鐗╀綋鍐呬笉鍚岀粍缁囧強浣撴恫涓垎甯冨強娴撳害宸紓澶с€備富瑕佺绫诲寘鎷細鑴傜被銆佹皑鍩洪吀銆佹湁鏈洪吀銆佺⒊姘村寲鍚堢墿銆佹牳閰哥瓑銆?/strong>

浠h阿缁勫”鏄郴缁熺爺绌朵唬璋㈢粍鐨勪竴闂ㄧ嫭绔嬪绉戯紝瀹冩彁渚涗簡鎵€鏈夌粏鑳炶繃绋嬬殑鐙壒鐢熷寲鎸囩汗锛屽彲鐢ㄤ簬閴村畾浠h阿鐢熺墿鏍囧織鐗╋紝浠庤€岄槓鏄庢綔鍦ㄧ殑鐤剧梾鏈哄埗锛屾垨棰勬祴瀵圭幆澧冨彉鍖栨垨澶栭儴骞查鐨勫弽搴斻€?/p>

鑴傝川缁勫” 鏄郴缁熺爺绌惰剛璐ㄧ粍鐨勪竴闂ㄧ嫭绔嬪绉戯紝 浣滀负澶ц妯″畾鎬у拰瀹氶噺鐮旂┒鑴傜被鍖栧悎鐗╁苟浜嗚В瀹冧滑鍦ㄤ笉鍚岀敓鐞嗐€佺梾鐞嗘潯浠朵笅鐨勫姛鑳藉拰鍙樺寲鐨勬柟娉曞, 鑳藉噯纭叏闈㈠湴鎻愪緵鐢熺墿鏍峰搧鍦ㄤ笉鍚岀敓鐞嗘潯浠朵笅鐨勫叏鑴備俊鎭氨鍥俱€?/p>

浠庝互涓婂畾涔夊彲浠ョ湅鍑猴紝“鑴傝川缁勫”瀹為檯涓婃槸“浠h阿缁勫”鐨勪竴涓垎鏀?/strong>銆備絾鏄紝鐢变簬鑴傜被浠h阿(濡傝娴嗕腑绾?0%鐨勪唬璋㈢墿鏄剛绫? 鏄姩妞嶇墿鐨勪唬璋腑绗竴澶х被锛屾槸鍔ㄦ鐗╀唬璋㈢爺绌朵腑鏈€涓哄叧娉ㄧ殑鐑偣锛屽弬涓庤兘閲忚繍杈撱€佺粏鑳為棿鐨勪俊鎭€氳涓庣綉缁滆皟鎺х瓑鐢熼暱鍙戣偛杩囩▼涓殑蹇呴渶浜嬩欢銆備綔涓虹粏鑳炶啘鍜岃剛婊寸殑涓昏缁勬垚鎴愬垎锛屽悇绉嶇粨鏋勭殑鑴傜被鍦ㄥ箍娉涚殑鐢熺墿瀛﹁繃绋嬶紝濡備俊鍙蜂紶瀵笺€佽繍杈撲綔鐢ㄤ互鍙婂叿鏈変笉鍚岀敓鍖栨€ц川鐨勭敓鐗╁ぇ鍒嗗瓙鍒嗛€夎繃绋嬩腑锛屾壆婕旂潃閲嶈瑙掕壊銆?strong>闅忕潃杩戝勾鏉ヨ剛璐ㄧ粍瀛﹁繀鐚涘彂灞? 绉戝瀹朵滑灏遍€愭笎灏嗚剛璐ㄧ粍鐨勭爺绌跺嵆“鑴傝川缁勫”浠?ldquo;浠h阿缁勫”涓崟鐙垝鍒嗗嚭鏉ワ紝鐜板湪鎴戜滑鎵€鎸囩殑“浠h阿缁勫”涓€鑸氨涓嶅啀鍖呮嫭绯荤粺鐨勮剛璐ㄧ粍鍒嗘瀽浜嗐€?/strong>

 

閫氳繃鑴傝川缁勫鐮旂┒锛岄槓閲婅剛璐ㄤ唬璋㈢浉鍏崇柧鐥呯殑鍙戠梾鏈虹悊

“鑴傝川鏄粏鑳炶啘鍜岃剛婊寸殑涓昏缁勬垚鎴愬垎锛屽湪骞挎硾鐨勭敓鐗╁杩囩▼锛屽淇″彿浼犲銆佽繍杈撲綔鐢ㄤ互鍙婄敓鐗╁ぇ鍒嗗瓙鍒嗛€夎繃绋嬩腑鎵紨鐫€閲嶈瑙掕壊銆傚鑴傝川鐨勫叏闈㈠垎鏋? 鍗宠剛璐ㄧ粍瀛︽槸浜嗚В缁嗚優鍙樺寲杩囩▼涓剛璐ㄧ粏寰殑鍔ㄦ€佸彉鍖栦互鍙婅嚧鐥呮満鐞嗙殑鍏堝喅鏉′欢銆?strong>鑴傝川浠h阿绱婁贡鍜岀敓娈栧彂鑲茬己闄峰強澶氱閲嶅ぇ鐤剧梾濡傜硸灏跨梾銆佸績琛€绠$柧鐥呫€佽剛鑲倽銆佽偉鑳栥€佺檶鐥囥€佽€佸勾鐥村憜绛夐噸澶х柧鐥呭瘑鍒囩浉鍏炽€?/strong>鑴傝川缁勬垚鍒嗙殑鍙樺寲鍙洿鎺ュ弽鏄犵敓鐗╀綋鐨勭敓鐞嗗拰鐥呯悊鐘舵€侊紝鍒嗘瀽缁勭粐鍣ㄥ畼鐢熼暱鍙戣偛杩囩▼涓剛璐ㄨ氨绾圭殑鍙樺寲鍙婅В鏋愮浉鍏充唬璋㈣皟鎺х綉缁滄満鍒跺叿鏈夐噸瑕佺殑鐢熺墿瀛︽剰涔夊拰涓村簥浠峰€笺€?/p>

绋庡厜鍘氳€佸笀棰嗚棣栧垱寮€鍙戜簡鍩轰簬MATLAB鑴傝川缁勫棰嗗煙鐨?strong>闈為澏鍚戞暟鎹垎鏋愭柟娉?/strong>涓庤蒋浠?FASEB J, 2006锛?J Lipid Res, 2007)锛屽甫鍔ㄥ拰淇冭繘浜嗛潪闈跺悜鑴傝川缁勫鐨勫彂灞曘€?闈為澏鍚戣剛璐ㄧ粍瀛﹀浜庢寲鎺樼┒鐢熺墿鏍峰搧鐨勮川璋卞垎鏋愪腑浣庝赴搴︾瀛愮殑鏄捐憲鍙樺寲銆佸挨鍏舵槸鍙戠幇鏈煡浠h阿鐗╀腑鍏锋湁涓嶅彲鎴栫己鐨勪綔鐢紝浣嗗湪瀹氭€у噯纭€у強鏁堢巼涓庡畾閲忔柟闈粛闈㈠宸ㄥぇ鎸戞垬锛屽苟涓嶉€傜敤浜庝复搴婂ぇ瑙勬ā搴旂敤鎴栫郴缁熺敓鐗╁澶ф牱鏈垎鏋愩€?/p>

绋庡厜鍘氳€佸笀鍥㈤槦杩愮敤SCIEX QTRAP®璐ㄨ氨寮€鍙戜簡涓€绯诲垪閫傜敤浜庣敓鐗╂牱鏈殑澶氱鐗╃鐨勯珮瑕嗙洊鑴傝川缁勭殑蹇€熼澏鍚戝畾閲忓垎鏋愭ā寮?/strong>锛圗MBO Mol Med, 2012锛?PNAS, 2013锛?J lipid Res, 2014锛?Neurobiol Aging, 2014锛?Redox Biol, 2017, Anal Chim Acta,2018锛夛紝鍙鍏ㄩ潰鐨勮剛璐ㄥ簱杩涜鍑嗙‘銆佸彲闈犵殑瀹氶噺鍒嗘瀽锛?骞舵垚鍔熷簲鐢ㄤ簬涓€绯诲垪鐢熺墿鍖诲鐨勫熀纭€鍜屼复搴婄殑閲嶈鐮旂┒涓紙PNAS, 2009, 2012, 2018, 2019锛汮CI, 2011锛?Nature, 2014锛?Nature Medicine, 2012锛?Molecular Cell, 2012锛?2014锛?Immunity, 2013锛?Cell Res, 2016锛?Development Cell, 2017锛?Science, 2018锛?EMBO J, 2018锛?Nature Comm., 2018锛夛紱杩?0骞存潵宸茬粡鍙戣〃100浣欑瘒SCI璁烘枃锛屾€诲奖鍝嶅洜瀛愯秴杩?00銆?/p>

绋庡厜鍘氾細涓轰粈涔堣鍋氳剛璐ㄧ粍瀛︾爺绌讹紵

鍩轰簬LC-MS/MS寤虹珛瀹氶噺鑴傝川缁勫垎鏋愭柟娉曠殑涓€鑸伐浣滄祦绋?/p>

锛圠am SM, Tian H, Shui G*. BBA-Mol Cell Biol L 2017鑴傝川缁勫涓撳垔灏侀潰鏂囩珷锛?/p>

 

鎺€璧疯剛璐ㄧ殑“绁炵闈㈢罕”

杩戝嚑骞达紝瓒婃潵瓒婂鐮旂┒鑰呰璇嗗埌闄や簡铔嬬櫧璐紝鑴傝川鍒嗗瓙鍦ㄧ敓鍛戒綋涓篃鍙戞尌閲嶈浣滅敤銆傝剛璐紝鏄竴绫昏嚜鐒剁晫瀛樺湪鐨勭枏姘存垨涓ゆ€х殑鏈夋満鐗╁皬鍒嗗瓙銆傜敱“鑴傝川浠h阿閫斿緞鐮旂┒璁″垝”锛圠ipid Metabolites and Pathways Strategy锛孡IPID MAPS)璧勫姪鐨勫浗闄呰剛璐ㄥ垎绫讳笌鍛藉悕濮斿憳浼氭彁鍑虹殑鑴傝川鍒嗙被绯荤粺锛屽皢鑴傝川澶т綋鍒嗕负鍏ぇ绫伙細

1. 鑴傝偑閰扮被 Fatty acyls锛孎A
2. 鐢樻补鑴傜被 GlyceroHpids锛孏L
3. 鐢樻补纾疯剛绫?/td> Glycerophospholipids锛孏P
4. 闉樿剛绫?/td> Sphingolipids锛孲P
5. 鍥洪唶鑴傜被 Sterol lipids锛孲L
6. 寮傛垔鐑唶鑴傜被 Prenol lipids锛孭R
7. 绯栬剛绫?/td> Saccharolipids锛孲L
8. 鑱氶叜绫?/td> Polyketides锛孭K

绋庡厜鍘氾細涓轰粈涔堣鍋氳剛璐ㄧ粍瀛︾爺绌讹紵

鐐瑰嚮鏌ョ湅澶у浘

 

甯歌涓昏澶х被鑴傝川鐨勪唬琛ㄧ粨鏋勫紡

锛圠am SM, Shui G*. J Genet Genomics 2013. 鑴傝川浠h阿涓撳垔灏侀潰鏂囩珷锛?/p>

鍦ㄥ墧闄ゅ弻閿綅缃紓鏋勪綋锛岀珛浣撶粨鏋勫紓鏋勪綋鍜宻n-鏋勫瀷寮傛瀯浣撴儏鍐典笅锛屾牴鎹父瑙佽剛璐ㄥ垎瀛愮粍鎴愭ā鍧楅娴嬬湡鏍哥粏鑳炲唴閮ㄨ嚦灏戞湁180,000绉嶈剛璐ㄧ被鍖栧悎鐗┿€傝剛璐ㄧ粨鏋勭殑澶氭牱鎬ц祴浜堜簡鍏跺绉嶉噸瑕佺殑鐗╃悊鍜岀敓鐗╁姛鑳斤細浣滀负缁嗚優鑶滅殑閲嶈缁勬垚閮ㄥ垎锛屼笉浠呯淮鎸佺粏鑳炶啘缁撴瀯绋冲畾锛屽苟涓斿弬涓庤皟鑺傚寘鎷墿璐ㄨ繍杈撱€佽兘閲忚浆鎹€佷俊鎭瘑鍒笌浼犻€掋€佺粏鑳炲彂鑲插拰鍒嗗寲浠ュ強缁嗚優澧炴畺涓庡噵浜″湪鍐呯殑璇稿鐢熷懡娲诲姩杩囩▼銆?/p>

缇庡浗绛夊彂杈惧浗瀹堕兘鍦ㄥ浗瀹跺眰闈㈤儴缃蹭簡瑙勬ā鎬ч」鐩剛璐ㄧ粍瀛﹁鍒掞紝鍒嗗埆宸插缓绔嬭仈鍚堝瀷鐨勮剛璐ㄧ粍瀛︾爺绌舵満鏋勶紝鍏朵腑褰卞搷鍔涙渶澶х殑鏄笂鏂囨彁鍒扮殑缇庡浗鐨凩IPID MAPS椤圭洰锛岃幏寰楃編鍥絅IH鐨勫鏈熸敮鎸佺殑鐮旂┒椤圭洰锛屽彇寰椾簡闈炲父鏈夊奖鍝嶇殑鎴愭灉銆?/p>

鎴戝浗灏氭湭寮€濮嬪紑灞曠被浼肩殑娉ㄩ噸浜庤仈鍚堝瀷鐨勮妯℃€х殑鐮旂┒锛屼絾杩戝勾鏉ヤ紬澶氱鐮旈櫌鏍¢兘鎰忚瘑鍒拌剛璐ㄧ粍瀛︾殑閲嶈鎬э紝绾风悍缁勫缓浜嗗悇鍏风壒鑹茬殑鑴傝川缁勫骞冲彴锛屼績杩涗簡鎴戝浗鑴傝川缁勫鐨勫彂灞曘€?/p>

 

鑴傝川缁勫鐨勪竴鑸爺绌舵祦绋?/strong>

鑴傝川缁勫鍒嗘瀽娴佺▼涓昏鍖呮嫭鐢熺墿鏍锋湰涓剛璐ㄧ殑鎻愬彇銆佸垎绂诲垎鏋愪互鍙婄浉搴旂殑鏁版嵁鍒嗘瀽绛夈€?/p>

绋庡厜鍘氾細涓轰粈涔堣鍋氳剛璐ㄧ粍瀛︾爺绌讹紵

鐐瑰嚮鏌ョ湅澶у浘

 

鑴傝川缁勫垎鏋愭祦绋?/p>

锛圠am SM, Shui G*. J Genet Genomics 2013. 鑴傝川浠h阿涓撳垔灏侀潰鏂囩珷锛?/p>

 

璐ㄨ氨鍒嗘瀽鎶€鏈姪鍔涜剛璐ㄧ粍瀛︾爺绌跺簲瀵规寫鎴橈紝濂嬪媷鍚戝墠鎺㈢储鏈煡

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鈼?濡備綍閫氳繃浠ヤ笅閫斿緞锛屼粠鑴傝川缁勭敓鎴愮殑澶ф暟鎹腑鑾峰緱鏈夌敓鐗╁鎰忎箟鐨勬ā寮忥細浠ヤ唬璋㈤€氳矾涓哄鍚戠殑鍒嗘瀽鏂规硶娑电洊杩炴帴鑴傝川鍜岄潪鑴傝川浠h阿鐗╁叧閿唬璋㈠垎鏀畾鍒剁殑鐢熺墿淇℃伅瀛︽柟娉曪紝瀹炵幇鐩存帴鍜屽揩閫熶唬璋㈤€氳矾娉㈠姩鏁版嵁鍙鍖栫瓑銆?/p>

绋庡厜鍘氾細涓轰粈涔堣鍋氳剛璐ㄧ粍瀛︾爺绌讹紵

鑴傝川缁勫畾閲忓噯纭害鐨勮浆鍙?/p>

锛圠am SM, Tian H, Shui G*. BBA-Mol Cell Biol L 2017鑴傝川缁勫涓撳垔灏侀潰鏂囩珷锛?/p>

 

绋庡厜鍘氳棰樼粍鐏儹鎷涜仒涓?mdash;—鐮旂┒浜哄憳鍜屽崥澹悗

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璇峰皢鎮ㄧ殑鐩稿叧瀹炲姏璇佹槑鏉愭枡閭欢鑷?ghshui@genetics.ac.cn

绋庡厜鍘氾細涓轰粈涔堣鍋氳剛璐ㄧ粍瀛︾爺绌讹紵

鎵爜鏌ョ湅鎷涜仒璇︽儏

 

鍏充簬SCIEX

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