浠婂ぉ鏄細

瀹為獙瀹よ祫璁綉

2018鍓?0鏈堢敓鐗╁尰瀛﹂浜戞 琚侀殕骞?鏇归洩娑涘強鏂戒竴鍏瓑涓婃

瀹為獙瀹よ祫璁綉鏃堕棿:2018-10-17 鐐瑰嚮: 娆?/span> 鐧惧害鎼滅储

銆愬璇汇€?/strong>缁忚繃鐗规畩鐨勭畻娉曪紝鎴戜滑寰楀埌浜?018骞村墠10涓湀涓浗鐢熺墿鍖诲椋庝簯姒滀汉鐗╁強鏈€鐏垎鐨?涓噸澶у鏈晫浜嬩欢锛岃兘澶熶笂姒滅殑椋庝簯浜虹墿/浜嬩欢锛岄兘鏇鹃暱鏃堕棿鍗犳嵁杩?00澶氫釜鍏敓鐗╁尰瀛﹀叕浼楀彿鐨勫ご鐗堝ご鏉°€?鍦ㄦ锛屾垜浠簿閫変簡鍏朵腑鐨?涓簨浠跺強16浣嶉浜戞浜虹墿銆傛垜浠鍏惰繘琛屼簡鍒掑垎锛屽垎鍒槸锛?鏄熺骇鐨?涓簨浠讹紝鍒嗗埆浣嶈璐濆皵濂栵紝......
TAG鏍囩锛?鏂戒竴鍏?/a> 琚侀殕骞?/a> 鐢熺墿鍖诲椋庝簯姒?/a> 鏇归洩娑?/a>

缁忚繃鐗规畩鐨勭畻娉曪紝鎴戜滑寰楀埌浜?018骞村墠10涓湀涓浗鐢熺墿鍖诲椋庝簯姒滀汉鐗╁強鏈€鐏垎鐨?涓噸澶у鏈晫浜嬩欢锛岃兘澶熶笂姒滅殑椋庝簯浜虹墿/浜嬩欢锛岄兘鏇鹃暱鏃堕棿鍗犳嵁杩?00澶氫釜鍏敓鐗╁尰瀛﹀叕浼楀彿鐨勫ご鐗堝ご鏉°€?/p>

鍦ㄦ锛屾垜浠簿閫変簡鍏朵腑鐨?涓簨浠跺強16浣嶉浜戞浜虹墿銆傛垜浠鍏惰繘琛屼簡鍒掑垎锛屽垎鍒槸锛?鏄熺骇鐨?涓簨浠讹紝鍒嗗埆浣嶈璐濆皵濂栵紝鍥藉鑷劧绉戝鍩洪噾鍙婂奖鍝嶅洜瀛愶紱浜旀槦绾х殑椋庝簯姒滀汉鐗╋紝鍙湁1浣嶏紝鏄?strong>琚侀殕骞?/strong>鍏堢敓锛涘洓鏄熺骇鐨勯浜戞浜虹墿锛屾湁4浣嶏紝鍒嗗埆鏄?strong>鏇归洩娑涳紝鏈卞仴搴凤紝鏂戒竴鍏?/strong>鍙婂悍鎸敓锛涗笁鏄熺骇鐨勯浜戞浜虹墿锛屾湁2浣嶏紝棰滃畞鍙婃堡瀵岄叕锛涗簩鏄熺骇鐨勯浜戞浜虹墿锛屾湁4浣嶏紝鍒嗗埆鏄閲嶅啗锛屾潕绾㈣壇锛屽瓩寮猴紙鍏嬮殕鐚达級锛屽垬涓囬噷锛涗竴鏄熺骇鐨勯浜戞浜虹墿锛屾湁5浣嶏紝閽卞浗鑻辩瓑锛堜箤榫熺殑鎬у埆鍐冲畾锛夛紝瑁寸鍗匡紙鍖栧鏂规硶鍒跺骞茬粏鑳炵殑绉戝鍘熺悊锛夛紝鍚磋摀涓斤紝鑳℃捣宀氾紙鎶戦儊鐥囧彂鐥呮満鍒讹級锛岄粠蹇楀悍锛?000浠芥按绋绘祴搴忥級銆?/p>

鍥戒汉涓鸿璐濆皵濂栨搷纰庝簡蹇冿紝浠庝粖骞寸殑涓€鏈堜唤鐢变簬璇鸿礉灏斿鍛樹細鐨勬€т笐闂伙紝鏂囧濂栬杩彇娑堬紱6鏈堜唤鐨勬椂鍊欙紝璇鸿礉灏斿畼鏂圭粓浜庡湪10鏈堜唤灏嗕細瀹e竷鑾峰鑰呭悕鍗曪紱10鏈?鏃ワ紝璇鸿礉灏斿畼鏂瑰甯冪敓鐞嗗尰瀛﹀棰佺粰浜咲avid Allison鍙奣asuku Honjo锛屽師鍥犳槸浠栦滑鍙戠幇璐熸€у厤鐤皟鑺傛不鐤楃檶鐥囩殑鐤楁硶鏂归潰鐨勮础鐚紱10鏈?鏃ワ紝鐗╃悊瀛﹀棰佺粰浜嗘縺鍏夌墿鐞嗛鍩燂紝鍒嗗埆鎺堜簣Arthur Ashkin锛孏erard Mourou鍜孌onna Strickland3浣嶅鑰咃紝浠ヨ〃褰颁粬浠湪婵€鍏夊棰嗗煙鐨勭獊鍑烘€ц础鐚紱10鏈?鏃ワ紝鍖栧濂栨巿浜團rances H. Arnold銆丟eorge P. Smith鍙奡ir Gregory P. Winter涓変綅绉戝瀹讹紝浠ヨ〃褰颁粬浠湪閰剁殑瀹氬悜杩涘寲鍙婂櫖鑿屼綋灞曠ず鍘熷垱鎬х殑宸ヤ綔銆傚彟澶栵紝瀵逛簬浠婂勾鐨勮璐濆皵鑷劧绉戝濂栵紝鎺堜簣浜?浣嶅コ鎬у強1浣嶆棩鏈瀛﹀锛屽紩璧蜂簡绉戝鐣岀殑鏋佸ぇ鐨勮璁恒€?/p>

2018骞?鏈?鏃ワ紝鍏竷浜嗗浗瀹舵澃鍑洪潚骞村熀閲戣幏寰楄€咃紝鍏辨湁200浣嶏紱鍦?鏈?9鏃ワ紝缁忚繃涓撳璇勫锛屽叡鏈?99浣嶆弧瓒虫潯浠讹紝鑾峰緱璧勫姪銆?/p>

2018骞?鏈?7鏃ワ紝鍥藉鑷劧绉戝鍩洪噾鍏竷銆傚浗瀹惰嚜鐒剁瀛﹀熀閲戝鍛樹細鍏卞畨鎺掍腑澶储鏀胯祫閲戣祫鍔╄鍒?56浜垮厓锛屾瘮2017骞寸殑248浜垮厓澧炲姞3.23%銆傛埅鑷?018骞?鏈?4鏃ワ紝鍏辨帴鏀朵緷鎵樺崟浣嶆彁浜ょ殑鍚勭被椤圭洰鐢宠219306椤癸紝鏍规嵁銆婂浗瀹惰嚜鐒剁瀛﹀熀閲戞潯渚嬨€嬪拰鐩稿叧绠$悊鍔炴硶鐨勮瀹氾紝璇勫璧勫姪42150椤癸紝鐩存帴璐圭敤2091307.35涓囧厓锛屽凡瀹屾垚鍏ㄥ勾璧勫姪璁″垝鐨?9.08%锛屽悇椤硅祫鍔╁伐浣滄寜璁″垝杩涘睍椤哄埄銆?/p>

2018骞?鏈?6鏃ワ紝鏈€鏂扮殑褰卞搷鍥犲瓙缁堜簬鍑烘潵銆侷SI姣忓勾鍑虹増JCR(銆婃湡鍒婂紩鐢ㄦ姤鍛娿€嬶紝鍏ㄧОJournal Citation Reports)銆侸CR瀵瑰寘鎷琒CI鏀跺綍鐨?800绉嶆牳蹇冩湡鍒?鍏夌洏鐗?鍦ㄥ唴鐨?000澶氱鏈熷垔(缃戠粶鐗?涔嬮棿鐨勫紩鐢ㄥ拰琚紩鐢ㄦ暟鎹繘琛岀粺璁°€佽繍绠楋紝骞堕拡瀵规瘡绉嶆湡鍒婂畾涔変簡褰卞搷鍥犲瓙(Impact Factor)绛夋寚鏁板姞浠ユ姤閬撱€備竴绉嶆湡鍒婄殑褰卞搷鍥犲瓙锛屾寚鐨勬槸璇ュ垔鍓嶄簩骞村彂琛ㄧ殑鏂囩尞鍦ㄥ綋鍓嶅勾鐨勫钩鍧囪寮曠敤娆℃暟銆備竴绉嶅垔鐗╃殑褰卞搷鍥犲瓙瓒婇珮锛屼篃鍗冲叾鍒婅浇鐨勬枃鐚寮曠敤鐜囪秺楂橈紝涓€鏂归潰璇存槑杩欎簺鏂囩尞鎶ラ亾鐨勭爺绌舵垚鏋滃奖鍝嶅姏澶э紝鍙︿竴鏂归潰涔熷弽鏄犺鍒婄墿鐨勫鏈按骞抽珮銆傚彟澶栵紝瀛﹁€呬篃鍥寸粫璇ユ€庝箞璇勪环绉戝鐨勭爺绌舵垚鏋滐紝鎺€璧蜂簡涓€闃靛ぇ璁ㄨ銆?/p>

琚侀殕骞?/p>

2018鍓?0鏈堢敓鐗╁尰瀛﹂浜戞 琚侀殕骞?鏇归洩娑涘強鏂戒竴鍏瓑涓婃

 

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鏇归洩娑?/p>

2018鍓?0鏈堢敓鐗╁尰瀛﹂浜戞 琚侀殕骞?鏇归洩娑涘強鏂戒竴鍏瓑涓婃

 

鏇归洩娑涘湪骞虫椂鍙互璇存槸鏈€浣庤皟鐨勪汉浜嗭紝浣嗘槸鍦ㄥ鏈柟闈㈠苟涓嶄綆璋冦€傛浌闆稕鎬绘槸鑳藉崰鎹悇涓鏈叕浼楀彿鐨勫ご鏉★紝涓昏鏈?涓噸澶т簨浠讹細1鏈?鏃ワ紝鏇归洩娑涙媴浠诲崡寮€澶у鏍¢暱锛?018骞?0鏈?1鏃ワ紝鏇归洩娑涚爺绌剁粍鍦–ell鍦ㄧ嚎鍙戣〃棰樹负“Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response”鐨勭爺绌惰鏂囷紝璇ヨ鏂囪〃鏄庣粏鑳炶川IFN-γR2鐨勮啘鏄撲綅鏄縺娲诲法鍣粏鑳炲厛澶╂€х粏鑳炲唴缁嗚弻鎰熸煋鍙嶅簲鎵€蹇呴渶鐨勶紝璇ョ爺绌堕€氳繃澶栧湪E-閫夋嫨绱犲弬涓庡缓绔嬩簡宸ㄥ櫖缁嗚優涓紩鍙戠殑淇″彿浼犲鐨勮寖渚嬶紝淇冭繘浜嗗姛鑳界殑褰㈡垚锛?018骞?鏈?6鏃ワ紝鏇归洩娑涚爺绌剁粍鍦–ell鍙戣〃棰樹负“Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response”鐨勭爺绌惰鏂囷紝璇ヨ鏂囨彮绀轰簡鍏嶇柅搴旂瓟璋冭妭涓殑闈炶鑼冭嚜鎴戣瘑鍒ā寮忥紝骞跺睍绀轰簡璇卞鎬?ldquo;鑷垜”lncRNA浣滀负鏈夋晥鍒嗗瓙璇遍サ鐨勯噸瑕佷綔鐢紝鍏舵椿璺冨湴楗卞拰RIG-I缁撳悎浣嶇偣浠ラ檺鍒?ldquo;鑷垜“RNA璇卞鐨勫厛澶╂€у厤鐤弽搴斿苟缁存寔鍏嶇柅绋虫€侊紝鍦ㄧ値鐥囨€х柧鐥呯鐞嗕腑鍏锋湁娼滃湪鐢ㄩ€斻€傚彟澶栵紝2018骞?鏈?0鏃ワ紝鏇归洩娑涚爺绌剁粍鍦–ell鍙戣〃棰樹负“Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression”鐨勭爺绌惰鏂囷紝璇ヨ鏂囩粨鏋滆瘉瀹炰汉绫籋CC鎮h€呬腑瀛樺湪鑴綼rtemin闃虫€х殑Ter缁嗚優锛屽苟鏄剧ず琛€娓卆rtemin鍗囬珮涓庨鍚庝笉鑹浉鍏炽€傛浌闆稕鐮旂┒缁勮〃鏄嶵er缁嗚優鍜屽垎娉岀殑artemin鍦ㄧ檶鐥囪繘灞曚腑鍙戞尌閲嶈浣滅敤锛屽叿鏈夐鍚庡拰娌荤枟鎰忎箟锛涘悓鏃?018骞?鏈?6鏃ワ紝鏇归洩娑涚爺绌剁粍鍦∟ature鍙戣〃棰樹负“Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation”鐨勭爺绌惰鏂囷紝璇ヨ鏂囨彮绀轰簡鍏堝墠鏈煡鐨凾et2鍦ㄨ〃瑙傞仐浼犺浆褰曟按骞崇殑璋冭妭浣滅敤锛屽湪鍝轰钩鍔ㄧ墿绯荤粺鎰熸煋鏈熼棿閫氳繃闄嶄綆mRNA涓殑5-mC锛屼績杩涙垚楠ㄧ粏鑳炵敓鎴愩€傛澶栵紝鑳炲槯鍟剁敳鍩哄寲瀵瑰弻閾綬NA褰㈡垚鍜宮RNA涓瑼dar1缁撳悎鐨勬姂鍒朵綔鐢ㄦ彮绀轰簡鍏跺湪鍝轰钩鍔ㄧ墿绯荤粺涓殑鏂扮殑鐢熺悊浣滅敤銆?/p>

鏈卞仴搴?/p>

2018鍓?0鏈堢敓鐗╁尰瀛﹂浜戞 琚侀殕骞?鏇归洩娑涘強鏂戒竴鍏瓑涓婃

 

鏈卞仴搴锋槸涓闄笂娴锋鐗╅€嗗鐢熺墿瀛︾爺绌朵腑蹇冧富浠汇€佺爺绌剁粍闀裤€佸崥澹敓瀵煎笀銆傚湪2018骞达紝鏈卞仴搴锋€绘槸涓嶆柇鐨勫湪鍒锋湅鍙嬪湀锛岃繖涓昏鏄洜涓烘湵鍋ュ悍鍥㈤槦鑱斿悎灞变笢甯堣寖澶у鎴愮珛鍩哄洜缂栬緫浜т笟鍥互鍙婅繛鍙?1绡囬珮姘村钩鐨勬枃绔狅紙鍏朵腑12绡囬€氳锛夛紝鍑犱箮鏄瘡闅斿嚑澶╋紝灏辨湁閲嶅ぇ鎴愭灉鍑烘潵锛岃繖12绡囨枃绔犲垎鍒槸锛?ldquo;Understanding the Molecular Basis of Salt Sequestration in Epidermal Bladder Cells of Chenopodium quinoa”鐨勭爺绌惰鏂囷紝璇ヨ鏂囨彮绀烘彮绀鸿棞楹﹁〃鐨粏鑳炰腑鐩愯灟鍚堢殑鍒嗗瓙鍩虹锛?ldquo;DNA demethylase ROS1 negatively regulates the imprinting of DOGL4 and seed dormancy in Arabidopsis thaliana”鐨勭爺绌惰鏂囥€傝鐮旂┒鍙戠幇浜嗘嫙鍗楄姤DNA鍘荤敳鍩哄寲閰禦OS1璐熻皟鎺OGL4鍩哄洜鐨勫嵃璁板拰绉嶅瓙浼戠湢鐨勬柊鏈哄埗锛?ldquo;Expanding the base editing scope in rice by using Cas9 variants”鐨勭爺绌惰鏂?璇ョ爺绌堕€氳繃鍒╃敤SpCas9鍜孲aCas9鐨勫彉浣撳紑鍙戜簡鏂扮殑鑵哄槍鍛ゅ拰鑳炲槯鍟剁⒈鍩虹紪杈戝櫒锛屽叾澶уぇ鎵╁睍浜嗘按绋诲熀鍥犵粍涓殑鍙澏鍚戜綅鐐广€?姝ゅ锛岃鐮旂┒杩樿〃鏄庤吅鍢屽懁鍜岃優鍢у暥纰卞熀缂栬緫鍣ㄥ彲浠ュ湪姘寸ɑ涓悓鏃惰繘琛屻€?鏁呰鐮旂┒鎶ラ亾鐨勬柊纰卞熀缂栬緫鍣ㄥ皢鍦ㄧ爺绌舵按绋诲姛鑳藉熀鍥犵粍瀛︿腑鍙戞尌浣滅敤锛屽苟灏嗘帹杩涗綔鐗╃殑绮剧‘鍒嗗瓙鑲茬锛?ldquo;Multiplex gene editing in rice with simplified CRISPR鈥怌pf1 and CRISPR鈥怌as9 systems”锛岃鏂囩珷寮€鍙戜簡绠€鍖栫殑CRISPR-Cpf1鍜孋RISPR-Cas9绯荤粺鍦ㄦ按绋讳腑杩涜澶氶噸鍩哄洜缂栬緫锛?ldquo;Mutations in a subfamily of abscisic acid receptor genes promote rice growth and productivity”锛岃鏂囩珷鎻ず浜嗚劚钀介吀鍙椾綋鍩哄洜浜氬鏃忎腑鐨勭獊鍙樹績杩涗簡姘寸ɑ鐨勭敓闀垮拰鐢熶骇鍔涳紱“Dynamics and function of DNA methylation in plants”锛岃鏂囩珷璁ㄨ浜嗚璁轰簡妞嶇墿涓殑DNA鐢插熀鍖栵紝鍖呮嫭鐢插熀鍖栧拰鍘荤敳鍩哄寲閰跺拰璋冩帶鍥犲瓙锛屼互鍙婇€氳繃鎵€璋撶殑鐢插熀鍖栫姸鎬佹満鍒跺崗璋冪敳鍩哄寲鍜屽幓鐢插熀鍖栨椿鎬э紱 DNA鐢插熀鍖栧湪璋冩帶杞骇瀛愭矇榛橈紝鍩哄洜琛ㄨ揪鍜屾煋鑹蹭綋鐩镐簰浣滅敤涓殑鍔熻兘锛?DNA鐢插熀鍖栧湪妞嶇墿鍙戣偛涓殑浣滅敤锛?浠ュ強DNA鐢插熀鍖栧弬涓庢鐗╁鐢熺墿鍜岄潪鐢熺墿鑳佽揩鏉′欢鐨勫弽搴旓紱“CRISPR/Cas9-mediated gene targeting in Arabidopsis using sequential transformation”锛岃璁烘枃鎶ラ亾浜嗘嫙鍗楄姤涓熀鍥犻澏鍚戠殑杩炵画杞寲-绮剧‘鍩哄洜闈跺悜鏂规硶銆備娇鐢ㄦ潵鑷嵉缁嗚優鍜屾棭鏈熻儦鑳庣壒寮傛€D45鍩哄洜鍚姩瀛愰┍鍔–as9锛?閫氳繃鍚屾簮閲嶇粍鍦ㄥ嚑涓唴婧愭€т綅鐐逛笂瀹氬悜鎻掑叆鏍囩鎴栬€呮槸杩涜姘ㄥ熀閰告浛鎹紝 杩欎簺鍙仐浼犵殑鍩哄洜闈跺悜鍙€氳繃甯歌PCR閴村畾锛?ldquo;Precise A·T to G·C Base Editing in the Rice Genome”锛岃繖閲屾弿杩扮殑鑵哄槍鍛ょ⒈鍩虹紪杈戝櫒涓庡叾浠栧熀鍥犵粍宸ョ▼宸ュ叿涓€璧峰皢鏈夊姪浜庢帹杩涗綔鐗╃殑绮剧‘鍒嗗瓙鑲茬锛?ldquo;A naturally occurring epiallele associates with leaf senescence and local climate adaptation in Arabidopsis accessions”璇ョ瘒鏂囩珷鎻ず浜咲NA鐢插熀鍖栵紙epiallele锛夊弬涓庡奖鍝嶈嚜鐒剁晫妞嶇墿鍙剁墖鐨勮“鑰佸叧绯汇€傝繖涔熸槸涓烘暟涓嶅鐨凞NA鐢插熀鍖栧奖鍝嶆鐗╄〃鍨嬬殑渚嬪瓙锛屽悓鏃朵篃鏄〃瑙傞仐浼犲弬涓庡叏鐞冩皵鍊欏彉鏆栬繃绋嬪緢濂界殑璇佹槑锛?ldquo;Knockdown of Rice MicroRNA166 Confers Drought Resistance by Causing Leaf Rolling and Altering Stem Xylem Development”锛岃鏂囩珷閴村畾浜嗚〃鐜板嚭miR166鏁蹭綆鍝佺郴锛圫TTM166锛夈€?STTM166姘寸ɑ妞嶆牚鐨勫彾鐗囧嵎鏇插彲鑳芥槸鐢变簬澶у皬鍑忓皯鐨勭孩鑹茬粏鑳炲拰鍙剁墖涓殑鍙剁姸缁嗚優鐨勫紓甯搞€?STTM166妞嶇墿鐨勬皵瀛斿搴﹂檷浣庯紝钂歌吘閫熺巼涓嬮檷銆傚垎瀛愬垎鏋愭彮绀轰簡HD-Zip III鍩哄洜瀹舵棌鐨勬垚鍛極sHB4浣滀负miR166鐨勪富瑕侀澏鏍囷紱“Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response”锛岃鏂囩珷鎻ず浜員OR淇″彿鎶戝埗ABA淇″彿浼犲鍜屽簲婵€鍙嶅簲锛岃€孉BA淇″彿鎶戝埗TOR淇″彿鍜屽簲婵€鏃堕棿鐨勭敓闀裤€傛鐗╁埄鐢ㄨ繖绉嶄繚瀹堢殑纾烽吀璋冭妭鍙嶉鏈哄埗鏉ヤ紭鍖栫敓闀垮拰鑳佽揩鍙嶅簲鐨勫钩琛★紱“Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA-Independent SnRK2 Activity”璇ヨ鏂囬€氳繃CRISPR/Cas9鎶€鏈暡闄や簡鍖呭惈14涓狿YLs瀹舵棌鎵€鏈夋垚鍛橈紝楠岃瘉浜嗕箣鍓岮BA淇″彿閫氳矾锛屽苟鎻ず浜哖YLs鍦ㄦ鐗╂笚閫忚儊杩搷搴斾腑閫氳繃鎶戝埗SnRK婵€閰舵椿鎬ц捣閲嶈浣滅敤銆?/p>

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2018鍓?0鏈堢敓鐗╁尰瀛﹂浜戞 琚侀殕骞?鏇归洩娑涘強鏂戒竴鍏瓑涓婃

鍦?018骞达紝鏂戒竴鍏兘鐧讳笂椋庝簯姒?鏄熺骇鐨勬鍗曪紝涓昏鏄叏鑱屽姞鐩熷垰鎴愮珛鐨勮タ婀栧ぇ瀛︼紝浠昏タ婀栧ぇ瀛︽牎闀垮強鍙戣〃浜?绡囬珮姘村钩鏂囩珷锛?鏈?鏃ワ紝鏂戒竴鍏湪Science鍙戣〃棰樹负“Structure of a human catalytic step I spliceosome”鐨勭爺绌惰鏂囷紝璇ヨ鏂囨彮绀轰簡瀵规牳绯栨牳铔嬬櫧閲嶆瀯鐨勬満鐞嗘€ц璇嗭紝骞跺厑璁稿垵姝ョ煡閬揅鍒癈 *杞彉鐨勫伐浣滄満鍒讹紱1鏈?3鏃ワ紝鏂戒竴鍏爺绌剁粍鍦–ell Research鏉傚織涓婂彂琛ㄤ簡棰樹负“Structure of the human activated spliceosome in three conformational states”鐨勭爺绌惰鏂囷紝璇ョ爺绌跺浜庝汉绫诲壀鍒囧鍚堜綋缁撴瀯鐨勮璇嗚繘涓€姝ュ姞娣憋紱2018骞?鏈堬紝鏂戒竴鍏爺绌剁粍鍦⊿cience鍙戣〃棰樹负“Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation”鐨勭爺绌惰鏂囷紝璇ヨ鏂囧垎鍒姤鍛婁簡閰块厭閰垫瘝B鍜宲re-B澶嶅悎鐗╃殑鍐峰喕鐢甸暅缁撴瀯锛屽钩鍧囧垎杈ㄧ巼鍒嗗埆涓?.3-4.6鍜?.9Å锛?缁撴瀯鍒嗘瀽鎻ず浜嗛叺姣嶅壀鎺ヤ綋鐨勮閰嶅拰婵€娲绘満鍒讹紱2018骞?鏈?0鏃ワ紝娓呭崕澶у鏂戒竴鍏爺绌剁粍鍦⊿cience鏉傚織鍦ㄧ嚎鍙戣〃棰樹负“Structure of the human PKD1/PKD2 complex”鐨勭爺绌惰鏂囷紝璇ヨ鏂囨姤鍛婁互1锛?姣斾緥缁勮鐨勬埅鐭殑浜篜KD1 / PKD2澶嶅悎鐗╃殑3.6Å鍐峰喕鐢靛瓙鏄惧井闀滅粨鏋勩€?鎬讳箣锛孭KD1 / PKD2澶嶅悎鐗╃殑杩戝師瀛愬垎杈ㄧ巼缁撴瀯鎻ず浜嗗紓瀵¤仛浣撳鍚堢墿瑁呴厤鐨勫垎瀛愮粏鑺傦紝骞舵彁渚涗簡鐢ㄤ簬缁樺埗澶ч噺鐤剧梾绐佸彉鐨勬ā鏉裤€?018骞?0鏈?2鏃ワ紝娓呭崕澶у鐢熷懡绉戝瀛﹂櫌鏂戒竴鍏洟闃熶笌闂垱涓氬洟闃熷悎浣滐紝鍦–ell Research涓婂彂琛ㄦ枃绔犮€奡tructures of the human pre-catalytic spliceosome and its precursorspliceosome銆嬨€傛枃涓紝鐮旂┒浜哄憳鎶ラ亾浜嗕汉婧恜re-B澶嶅悎鐗╁拰浜烘簮B澶嶅悎鐗╃殑鍐峰喕鐢甸暅缁撴瀯锛屽叾骞冲潎鍒嗚鲸鐜囧垎鍒负5.7鍜?.8

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棰滃畞鍦?018骞村湪Science鍙戣〃浜?绡囨枃绔狅細2018骞?鏈?鏃ワ紝棰樹负“Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1”鐨勭爺绌惰鏂囷紝璇ヨ鏂囨姤鍛婁汉绫籒av1.4-β1澶嶅悎鐗╃殑鍐峰喕EM缁撴瀯锛屽垎杈ㄧ巼涓?.2Å锛?018骞?鏈?7鏃ワ紝鍙戣〃棰樹负“Structural basis for the modulation of voltage-gated sodium channels by animal toxins”鐨勭爺绌惰鏂囷紝璇ヨ鏂囧緱鍒颁簡鏄嗚櫕Nav閫氶亾NavPaS鐨勭粨鏋勶紝鍏剁粨鍚堜簬2.8Å鐨勯棬鎺т慨楗版瘨绱燚c1a锛屽苟涓斿湪TTX鎴朣TX鐨勫瓨鍦ㄤ笅鍒嗗埆浠?.6Å鍜?.2Å鐨勫垎杈ㄧ巼缁撳悎锛?018骞?鏈?9鏃ワ紝鍙戣〃棰樹负 “Structural basis for the recognition of Sonic Hedgehog by human Patched1”鐨勭爺绌惰鏂囷紝璇ヨ鏂囨姤鍛婁簡浜虹被Ptch1鍙奝tch1涓嶴hhN澶嶅悎鐗╃殑鏁翠綋鍒嗚鲸鐜囧垎鍒负3.9Å鍜?.6Å鐨勫喎鍐荤數闀滅粨鏋勩€?/p>

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鐢变簬鍓嶆鏃堕棿鐨勭Н绱紝姹ゅ瘜閰洟闃熷湪1鏈?鏃ヨ幏寰椾簡鍥藉鑷劧绉戝2绛夊銆傚彟澶栵紝姹ゅ瘜閰洟闃熶粖骞村浜庝竴涓ぇ鐖嗗彂闃舵锛屽彂琛ㄤ簡10绡囬珮姘村钩鐨勬枃绔狅紙鍖呮嫭涓€绡囪瘎璁烘枃绔狅級锛岃繖浜涙枃绔犲垎鍒槸锛氬寳浜ぇ瀛︽堡瀵岄叕绛夌爺绌剁粍鍦∟ature Cell Biology涓婂湪绾垮彂琛ㄤ簡棰樹负“Single-cell multi-omics sequencing of human early embryos”鐨勬枃绔狅紝鐮旂┒浜哄憳搴旂敤鍗曠粏鑳炴煋鑹茶川鏁翠綋鐨勫ぇ瑙勬ā鏅娴嬪簭锛坰cCOOL-seq锛夋潵鐢熸垚浜虹被妞嶅叆鍓嶅彂鑲叉湡闂村崟缁嗚優鍒嗚鲸鐜囩殑DNA鐢插熀鍖栧拰鏌撹壊璐ㄥ彲鍙婃€х殑鍏ㄥ熀鍥犵粍鍥捐氨銆傝鐮旂┒宸ヤ綔涓哄墫鏋愪汉绫绘鍏ュ墠鍙戣偛杩囩▼涓鏉傝€屽張楂樺害鍗忚皟鐨勮〃瑙傞仐浼犻噸缂栫▼閾哄钩浜嗛亾璺紱Cell Research“Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis”锛岀爺绌剁‘瀹氫簡29涓粏鑳炰簹缇わ紝杩欎簺浜氱兢鍦ㄦ瘡涓尯鍩熸樉绀哄嚭涓嶅悓鐨勬瘮渚嬶紝骞朵笖鑴戞ˉ鏄剧ず鍑虹壒鍒珮鐨勬槦褰㈣兌璐ㄧ粏鑳炵櫨鍒嗘瘮锛汵ature锛欰 Single-cell RNA-Seq survey of the developmental landscape of the human prefrontal cortex锛屾彮绀轰簡绁炵粡鍏冧骇鐢熷拰鐜矾褰㈡垚鐨勫垎瀛愯皟鎺ф満鍒讹紝骞跺鍏朵腑鍏抽敭鐨勭粏鑳炵被鍨嬭繘琛屼簡绯荤粺鐨勫姛鑳界爺绌讹紝涓虹粯鍒舵渶缁堝畬鏁寸殑浜鸿剳缁嗚優鍥捐氨锛屽瀹氫簡閲嶈鐨勫熀纭€锛汵ature Cell Bio:Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing锛岀郴缁熷湴闃愭槑浜嗛閬撱€佽儍銆佸皬鑲犲拰澶ц偁4绉嶅櫒瀹樺湪浜虹被鑳氳儙鍙戣偛杩囩▼涓殑鍩哄洜琛ㄨ揪鍥捐氨鍙婂叾淇″彿璋冩帶鏈哄埗锛屼负娑堝寲閬撶敓鐗╁鐮旂┒棰嗗煙鎻愪緵浜嗗叏闈€佺繑瀹炵殑鍙戣偛缁嗚優鍥捐氨鏁版嵁銆傦紱Nature Genetics锛歋ingle-cell DNA Methylome Sequencing of Human Preimplantation Embryos锛屽埄鐢ㄥ崟缁嗚優DNA鐢插熀鍖栫粍楂橀€氶噺娴嬪簭鏂规硶锛岄娆″湪鍗曠粏鑳炲垎杈ㄧ巼瀵逛汉绫绘鍏ュ墠鑳氳儙鍙戣偛杩囩▼杩涜浜嗘洿鍔犳繁鍏ョ殑鍒嗘瀽锛屾彮绀轰簡浜虹被鏃╂湡鑳氳儙DNA鍘荤敳鍩哄寲鍜屼粠澶村姞鐢插熀鍖栫殑鍔ㄦ€佸彉鍖栥€佺埗姣嶆湰鍩哄洜缁勫樊寮傜敳鍩哄寲绛夊叧閿壒寰併€傦紱Cell Res:Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages锛岃繖涓€鐮旂┒缁撴灉涓洪槓鏄庝笉鍚岃〃瑙傝皟鎺у缁嗚優鍛借繍鍙婂彂鑲插彲濉戞€х殑褰卞搷銆佽璇嗗共缁嗚優鐨勫叏鑳芥€т笌鍒嗗寲娼滆兘浠ュ強骞茬粏鑳炶浆鍖栧尰瀛﹀簲鐢ㄧ瓑鎻愪緵浜嗗叏鏂扮殑瑙嗚鍜岀悊璁烘寚瀵笺€傦紱Nature Biot:Boosting the power of single-cell analysis锛屽Haghverdi绛変汉鍜孊utler鍦ㄧ嫭绔嬪崟缁嗚優鏁版嵁闆嗙殑鍏冨垎鏋愯繃绋嬩腑浜х敓鐨勫鐞嗘晥搴旓紝浠栦滑灞曠ず浜嗚繖浜涙柟娉曟槸濡備綍鍙戠幇鏂扮殑鐢熺墿鍙樺紓鍜屾柊鐨勭粏鑳炵被鍨嬬殑锛屾殫绀轰簡閫氳繃鎸栨帢鐜版湁鏁版嵁闆嗗彲浠ヨ幏寰楁洿澶氱殑鏈煡鑱旂郴鐨勮瘎璁烘枃绔狅紱鍦–ell Reports涓婂湪绾垮彂琛ㄤ簡棰樹负“Dissecting the global dynamic molecular profiles of human fetal kidney development by single-cell RNA sequencing”鐨勭爺绌惰鏂囷紝鏁翠釜宸ヤ綔鍥寸粫鑲捐剰鍙戣偛杩囩▼涓畬鏁磋偩鍗曚綅褰㈡垚杩欎竴鏍稿績鐢熺墿瀛︿簨浠讹紝璇︾粏闃愯堪浜嗚捣濮嬭偩鍗曚綅褰㈡垚鐨勫墠浣撶粏鑳炵殑寮傝川鎬э紝鍒嗘瀽浜嗙敱鑲惧崟浣嶅墠浣撶粏鑳為€愭鍒嗗寲浜х敓涓嶅悓绫诲瀷鐨勮偩灏忕涓婄毊缁嗚優杩囩▼涓搴旂殑杞綍璋冩帶浜嬩欢鍜屼俊鍙烽€氳矾璋冭妭鏈哄埗銆傚悓鏃惰鐮旂┒涔熼噸鐐瑰睍鐜颁簡鐩墠宸茬粡閴村畾鐨勫厛澶╂€ц偩鐥呯殑鍊欓€夎嚧鐥呭熀鍥犲湪鑳氳儙鏈熻偩鑴忎腑鐨勮〃杈剧壒鐐广€?/p>

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娴欐睙涓囬噷瀛﹂櫌钁涙澶╋紝閽卞浗鑻卞強鏉滃厠澶уCapel鐮旂┒缁勫悎浣滃湪Science鏉傚織鍙戣〃棰樹负“The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species”鐨勭爺绌惰鏂囷紝鏈爺绌堕娆℃槑纭簡榫熺被鐗╃琛ㄨ閬椾紶鏈哄埗涓庢俯搴︿緷璧栨€у埆鍐冲畾涔嬮棿鐨勫洜鏋滃叧绯诲拰鐩存帴閬椾紶鑱旂郴銆傚悓鏃惰鐮旂┒瑙e喅浜嗗洶鎵板ぇ瀹?0骞寸殑鎬у埆鍐冲畾闂锛岀敱浜庤繖涓爺绌剁殑杞板姩鎬у強鏂伴鎬э紝Science瀵规杩涜浜嗕笓闂ㄧ殑鎶ラ亾銆傚彟澶栵紝iNature鍙戠幇锛岃繖涔熸槸娴欐睙涓囬噷瀛﹂櫌棣栨浠ョ涓€鍗曚綅鍦⊿cience鏉傚織鍙戣〃鏂囩珷锛岃繖鍦ㄥ彟涓€鏂归潰璇存槑锛屾禉姹熶竾閲屽闄㈢殑鍩虹鐮旂┒鎱㈡參鐨勫湪杩涙锛岃繖涓庡鏍¢暱鏈熸敮鎸佸熀纭€鐮旂┒鍒嗕笉寮€銆?/p>

瑁寸鍗垮洟闃?/p>

涓浗绉戝闄㈠箍宸炵敓鐗╁尰鑽笌鍋ュ悍鐮旂┒闄㈣4绔嵖鐮旂┒鍛橀琛旂殑鐮旂┒鍥㈤槦缁忚繃5骞存敾鍏筹紝鎻ず浜嗗寲瀛︽柟娉曞埗澶囧共缁嗚優鐨勭瀛﹀師鐞嗭紝涓鸿瀵煎鑳藉共缁嗚優鐨勭爺绌跺拰浼樺寲鍒跺閫斿緞鎻愪緵浜嗗叏鏂扮殑绉戝瑙嗚鍜岃В鍐虫柟妗堛€傜浉鍏虫垚鏋滀簬2018骞?鏈?鏃ラ浂鏃跺湪绾垮彂琛ㄥ湪鍥介檯骞茬粏鑳炴潈濞佹潅蹇桟ell Stem Cell(缁嗚優·骞茬粏鑳?涓娿€傝4绔嵖鐮旂┒鍛橀琛旂殑绉戠爺鍥㈤槦缁忚繃锛曞勾鐨勫姫鍔涳紝寮€鍙戝嚭涓€濂楅珮鏁堛€佺畝鍗曠殑鍖栧灏忓垎瀛愯瀵煎鑳藉共缁嗚優鐨勬柟娉曪紝 绠€绉颁负CIP锛圕hemical Induction of Pluripotency锛夛紝鍗冲寲鍚堢墿璇卞骞茬粏鑳炲鑳芥€с€傝鏂规鍙渶瑕佺敤涓ょ涓嶅悓鐨?ldquo;鑽按”渚濇缁欑粏鑳?ldquo;娲楁尽”锛屼究鍙互灏嗕綋缁嗚優“杩旇€佽繕绔?rdquo;鍒板共缁嗚優鐨勭姸鎬併€傝繖涓€鏂规硶姣斾箣鍓嶇殑鏂规绠€鍗曘€侀珮鏁堬紝鎵€闇€鐨勫垵濮嬬粏鑳為噺灏戙€傛洿閲嶈鐨勬槸锛屽彲浠ュ疄鐜板绉嶄綋缁嗚優绫诲瀷“杩旇€佽繕绔?rdquo;锛屽寘鎷湪浣撳鏋侀毦鍩瑰吇鐨勮倽缁嗚優銆?/p>

鍚磋摀涓?/p>

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鑳℃捣宀?/p>

2鏈?5鏃ワ紝娴欐睙澶у鑳℃捣宀氱瓑鐮旂┒缁勫湪Nature鍙戣〃浜?绡囪儗闈犺儗鍦扮爺绌惰鏂囷紝棰樼洰鍒嗗埆涓?ldquo;Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression”鍙?ldquo;Ketamine blocks bursting in the lateral habenula to rapidly relieve depression”锛岃繖淇╃瘒鐮旂┒璁烘枃鎻ず浜嗗湪澶ц剳澶栦晶缂版牳涓殑绁炵粡鍏冩椿鍔紝鐢辨槦褰㈣兌璐ㄧ粏鑳炶皟鑺傦紝淇冧娇鍟娇绫诲姩鐗╁嚭鐜版姂閮佹牱琛屼负锛氭帹杩涗簡浜虹被瀵逛簬鎶戦儊鐥囧彂鐥呮満鍒剁殑杩涗竴姝ユ繁鍏ョ悊瑙o紝鍚屾椂杩欎竴鍙戠幇鍙兘鏈夊姪浜庢垜浠繘涓€姝ュ紑鍙戞柊鐨勬姂閮佽嵂鐗┿€?/p>

榛庡織搴?/p>

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